$79.99
This formulation combines two synthetic heptapeptides developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, supplied here in a spray format.
Selank is studied as a positive allosteric modulator of the GABAergic system. Research published in PMC has examined its activity in rodent stress models in comparison with classical benzodiazepine reference compounds [1], and a separate study examined how Selank is associated with the expression of genes involved in GABAergic neurotransmission [2]. These studies support allosteric modulation of the GABAergic system as a proposed molecular mechanism examined in laboratory models [1], [2].
As a tuftsin analogue, Selank has been examined for modulation of interleukin-6 expression and T helper cell cytokine balance, for association with monoamine neurotransmitter concentrations and serotonin metabolism, and for association with hippocampal BDNF expression in rats [1], [2]. These properties make Selank a research tool spanning GABAergic, immunomodulatory, and neurochemical investigation.
Semax is among the most extensively studied Russian-developed regulatory peptides. Literature has examined changes in BDNF levels and gene expression and TrkB-related signaling in association with Semax [3], and characterized it as an ACTH(4-10) analogue with nootropic-class activity [3]. Additional studies have examined its binding to neural tissue, making it a tool compound in neuroplasticity-pathway research [4].
Semax has been used in preclinical cerebral ischemia and oxidative-stress models as a research tool. Gene expression studies have examined how Semax is associated with the expression of genes related to neural and vascular function in rat brain [4]. This provides a molecular basis for the neuroprotection research framing applied to the compound [3], [4].
Because this formulation is supplied as a spray, it is of interest in research on peptide delivery and handling characteristics. This blend provides a model system for investigating peptide stability and recovery in solution and the comparative behavior of the two components under controlled laboratory conditions [1], [3].
This formulation combines two synthetic heptapeptides developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, supplied here in a spray format. Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is an analogue of the immunomodulatory peptide tuftsin, studied as a positive allosteric modulator of the GABAergic system with additional serotonergic and immunomodulatory activity. Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is an analogue of the adrenocorticotropic hormone ACTH(4-7) fragment, studied for its association with the neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Each peptide carries a C-terminal Pro-Gly-Pro motif that confers resistance to enzymatic degradation. The two are frequently studied together because they share a structural design strategy and a central nervous system research field while engaging pharmacologically distinct mechanisms. This product is for laboratory research use only and is not for human consumption.
The following citations are drawn from publications indexed on PubMed (pubmed.ncbi.nlm.nih.gov), PubMed Central (pmc.ncbi.nlm.nih.gov), and PubChem (pubchem.ncbi.nlm.nih.gov).
This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.
