SNAP-8 vs Argireline: two SNAP-25 mimic peptides compared
SNAP-8 and Argireline are synthetic peptides modeled on the N-terminal end of SNAP-25, one of the proteins that form the SNARE complex involved in vesicle fusion. SNAP-8 is a longer version of Argireline.
Side by side
| Argireline | SNAP-8 | |
|---|---|---|
| INCI name | Acetyl Hexapeptide-3 (also -8) | Acetyl Octapeptide-3 |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
| Length | 6 residues | 8 residues |
| Molecular weight | ≈ 889 g/mol | ≈ 1075.2 g/mol |
| CAS | 616204-22-9 | 868844-74-0 |
The SNARE complex
The SNARE complex is formed by SNAP-25, syntaxin and synaptobrevin, and it drives the fusion of vesicles with the cell membrane. Both peptides reproduce part of the SNAP-25 N-terminus and are designed to compete with it for a position in the complex.
Published research
- Acetyl hexapeptide-3 was characterized in vitro for interference with SNARE-complex formation (Blanes-Mira et al., Int. J. Cosmet. Sci., 2002).
- SNAP-8 extends that sequence by Ala-Asp. Most published work on it comes from cosmetic-chemistry and formulation research.
Handling notes
Both peptides are N-acetylated and C-amidated, which removes the charged termini. They contain methionine, which can oxidize, so vials should be kept sealed and away from light. A mass spectrometry result about 16 units above the expected mass can indicate methionine oxidation. See reading the mass spectrometry panel.
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- How to read a certificate of analysis (COA)
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View SNAP-8 and its per-lot certificate of analysis
For laboratory research use only. Not for human or veterinary use. This guide summarizes published scientific literature for context. It is not medical advice and does not describe any product as suitable for human use.