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MOTS-C
Single Peptides

MOTS-C

Made in the USA9 COAs

MOTS-C is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene.

In stock

Size

$69.99$7.00/mg
Latest COA for this sizeBatch 1418 · 99.8%Bioviridian · Jul 29, 2026 · COA6565
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  • QR on the back labelScan it to open the latest COA for this compound

Research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.

Lab results for MOTS-C

Each COA is issued by a third-party lab.

BioviridianHPLC purity, mass-spec identity
Third-party COA
99.8%

HPLC purity on the latest COA

Batch1418
Size tested10 mg
COA issuedJul 29, 2026
Verification codeCOA6565

All 9 COAs for MOTS-C

Research profile

MOTS-c research profile

MOTS-c is a 16-residue peptide encoded by a short open reading frame inside the mitochondrial 12S rRNA gene (MT-RNR1). It was discovered by Changhan Lee and colleagues in Pinchas Cohen's laboratory and reported in Cell Metabolism in 2015, making it one of the best-known mitochondrial-derived peptides.

Specifications

Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)
Molecular formula
C101H152N28O22S2
Molecular weight
≈ 2174.6 g/mol
CAS number
1627580-64-6
Sizes
10 mg, 20 mg and 40 mg
Form
Lyophilized powder, sealed vial
Storage
Keep sealed, protected from light and moisture; follow the label
Testing
Third-party COAs on tested batches (HPLC purity, mass spectrometry identity). The QR code on the label opens the latest one for this compound.

Published research

  • Discovery and metabolic signalling: cultured cells and diet-induced obesity mouse models, AMPK and folate-cycle pathways (Lee et al., Cell Metab, 2015).
  • Exercise and aging: aged-mouse studies; MOTS-c levels in plasma and muscle measured around exercise (Reynolds et al., Nat Commun, 2021).
  • Cardiac models: diabetic rat myocardial injury (Tang et al., Sci Rep, 2023).
  • Reviews of the mitochondrial-derived peptide family: Mohtashami et al., Int J Mol Sci, 2022; Wan et al., J Transl Med, 2023.
Read the guide MOTS-c: the mitochondrial-derived peptide explained

Frequently asked questions

What is a mitochondrial-derived peptide?

A peptide encoded within mitochondrial DNA rather than the nuclear genome. MOTS-c is encoded in the 12S rRNA gene.

What sizes are available?

10 mg, 20 mg and 40 mg.

Where do I find the certificate of analysis?

The QR code on the label opens the latest third-party certificate of analysis (COA) for this compound. You can also search the COA Portal by compound or batch number.

For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Literature references are provided for scientific context and do not describe this product's suitability for any use.

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MOTS-C is part of these research bundles. See all bundles

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Volume to measure0.05 mL50 µL
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