Single Peptides

5-Amino 1MQ

Name: 5-Amino 1MQ
Brand: LA Peptides
SKU: 5-amino-1mq
Availability: InStock

Made in the USA4 COAs

5-Amino 1MQ (5-amino-1-methylquinolinium) is a small-molecule NNMT inhibitor, not a peptide.

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Research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.

Lab results for 5-Amino 1MQ

Each COA is issued by a third-party lab.

BioviridianHPLC purity, mass-spec identity

Third-party COA

99.84%

HPLC purity on the latest COA

Batch1518

Size tested50 mg

COA issuedSep 5, 2026

Verification codeCOA8254

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All 4 COAs for 5-Amino 1MQ

Research profile

5-Amino-1MQ research profile

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule quaternary quinolinium cation that inhibits nicotinamide N-methyltransferase (NNMT) by binding at the nicotinamide substrate site. It came out of a structure-activity study of N-methylated aromatic scaffolds by Neelakantan, Watowich and colleagues at the University of Texas Medical Branch in 2017. It is usually supplied as the iodide salt.

Specifications

Chemical name: 5-Amino-1-methylquinolin-1-ium (iodide salt)
Molecular formula: C10H11N2+ (cation); C10H11N2·I (iodide salt)
Molecular weight: ≈ 159.2 g/mol (cation); 286.1 g/mol (iodide salt)
CAS number: 42464-96-0 (iodide salt)
Target: Nicotinamide N-methyltransferase (NNMT), IC50 ≈ 1.2 µM
Size: 50MG per vial
Form: Lyophilized powder, sealed vial
Storage: Keep sealed, protected from light and moisture; follow the label
Testing: Third-party COAs on tested batches (HPLC purity, mass spectrometry identity). The QR code on the label opens the latest one for this compound.

Published research

Structure-activity relationships of quinolinium and related NNMT inhibitors, with docking to the substrate site (Neelakantan et al., J Med Chem, 2017).
Permeability (PAMPA, Caco-2), selectivity against related methyltransferases, and 1-methylnicotinamide, NAD+ and SAM levels in cultured adipocytes (Neelakantan et al., Biochem Pharmacol, 2018).
The same 2018 study measured body weight, white adipose mass and plasma cholesterol in diet-induced obese mice.
Target background: NNMT knockdown in adipose tissue and liver of mice (Kraus et al., Nature, 2014).

Frequently asked questions

What does NNMT do?

It transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide.

Why do two molecular weights appear?

The active species is the cation (≈ 159.2 g/mol); it is supplied as a salt, usually the iodide (286.1 g/mol). The COA states the form tested.

Where do I find the certificate of analysis?

The QR code on the label opens the latest third-party certificate of analysis (COA) for this compound. You can also search the COA Portal by compound or batch number.

For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Literature references are provided for scientific context and do not describe this product's suitability for any use.