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Capsules
Dihexa Capsules
$79.99
Manufactured in the USA
Lot-tracked production
Protective packaging
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Description
Dihexa, a synthetic angiotensin IV–derived compound, in capsule format for formulation research. For laboratory research use only. Not for human or veterinary use.
Research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease.
Research profile
Dihexa research profile
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, also PNB-0408) is a small peptidomimetic derived from angiotensin IV. It was developed by Joseph Harding's group at Washington State University, who reported that it binds hepatocyte growth factor (HGF) and enhances HGF activity at its receptor, c-Met. Its phosphate prodrug, fosgonimeton, has been examined in early clinical research.
Specifications
- Structure
- Hexanoyl-Tyr-Ile-NH-(CH2)5-CONH2 (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide)
- Molecular formula
- C27H44N4O5
- Molecular weight
- ≈ 504.7 g/mol
- CAS number
- 1401708-83-5
- Form
- Supplied in capsule format
- Storage
- Keep sealed, protected from light and moisture; follow the label
- Testing
- HPLC purity and mass spectrometry identity, per lot. Scan the QR code on the vial for the certificate of analysis.
Published research
- Design and evaluation: metabolically stabilized angiotensin IV analogs, liver microsome stability, hippocampal synaptogenesis in culture, and scopolamine-treated and aged rats in the Morris water maze (McCoy et al., J Pharmacol Exp Ther, 2013).
- HGF/c-Met dependence of synaptogenic and behavioural measures in rats and cultured hippocampal neurons (Benoist et al., J Pharmacol Exp Ther, 2014). The journal later published a notice of concern about possible image manipulation in this article.
- Earlier C-terminally truncated Nle1-angiotensin IV analogs and dendritic spine formation (Benoist et al., J Pharmacol Exp Ther, 2011).
- Zebrafish lateral-line hair cells exposed to aminoglycosides (Uribe et al., Front Cell Neurosci, 2015).
- Review of the brain HGF/c-Met system: Wright & Harding, J Alzheimers Dis, 2015.
Frequently asked questions
Is dihexa a peptide?
It is a modified dipeptide (Tyr-Ile) with an N-terminal hexanoyl group and a C-terminal 6-aminohexanoic amide, often described as a peptidomimetic.
What formats are available?
Dihexa is supplied in capsule format and in spray format, for laboratory research only.
How do I verify my lot?
Scan the QR code on the vial. It opens the certificate of analysis for that lot, with HPLC purity and the mass spectrometry identity result.
For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Literature references are provided for scientific context and do not describe this product's suitability for any use.
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