$169.99
SMOOTH is a multi-peptide topical research lotion combining GHK-Cu, SNAP-8, and KPV. It is intended for in vitro and ex vivo models examining neuromuscular junction signaling, neuropeptide–SNARE interactions, copper-mediated matrix modulation, and pro-resolving inflammatory pathways at the skin interface.
SMOOTH integrates three mechanistically distinct components: GHK-Cu for copper transport and ECM-related signaling,[1] SNAP-8 (Acetyl Octapeptide-3) as a SNAP-25–mimetic peptide used to study SNARE complex interactions and exocytosis,[2] and KPV (Lys-Pro-Val), an α-MSH-derived tripeptide investigated for anti-inflammatory and barrier-supportive effects in epithelial systems.[3,4] This combination provides a versatile platform for dissecting how neuromodulatory, matrix-regulating, and pro-resolving peptide signals converge in cutaneous models, without suggesting cosmetic claims.
SNAP-8 is utilized to probe competitive interference with SNARE-mediated vesicle fusion and neurotransmitter release.[2] In a topical research format, it supports analysis of neuromuscular tension, neuronal input, and secretory activity in skin–muscle co-cultures or innervated 3D models, focusing on vesicle trafficking endpoints.
GHK-Cu contributes documented effects on collagen synthesis, MMP regulation, and antioxidant gene expression in dermal models.[1] SMOOTH enables controlled assessment of how copper-peptide signaling influences structural protein expression, integrin dynamics, and redox status when co-present with neuromodulatory peptides.
KPV has been studied for its ability to modulate pro-inflammatory cytokines and support epithelial integrity in preclinical systems.[3,4] Within SMOOTH, it offers a tool to evaluate anti-inflammatory signaling cascades and barrier-associated readouts alongside neuromuscular and ECM endpoints.
This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.
