Repair & Fix

Molecular Overview

BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide derived from a sequence of a gastric protective protein. Chemically described as C₆₂H₉₈N₁₆O₂₂, it has been examined for its influence on angiogenesis and cellular migration under in-vitro models .

TB-500, a research synonym for Thymosin β-4 fragment (Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr) [C₁₁₂H₁₇₇N₃₅O₄₆S], is studied for its role in actin-binding regulation and cell migration relevant to tissue repair models.

Research Applications

1. Cellular Regeneration and Cytoskeletal Studies

BPC-157 has been used in cell culture assays investigating its effect on fibroblast activity, migration, and cytoskeletal organization .

TB-500 research focuses on G-actin polymerization and cellular motility mechanisms . Combined, they provide a dual model system for evaluating peptide-mediated cytoskeletal repair signaling.

2. Angiogenesis and Endothelial Research

Both peptides have been assessed for their influence on VEGF-regulated endothelial behavior and microvascular remodeling in laboratory settings .

The co-formulation allows exploration of peptide synergy in vascular endothelial cell assays.

3. Oxidative and Stress Response Pathways

Experimental evidence indicates BPC-157 may modulate oxidative pathways, providing a useful control peptide in stress-response assays.

TB-500’s G-actin stabilization role supports comparative studies on cytoskeletal integrity under oxidative stress.

Referenced Citations

1. PubChem CID 9941957 – BPC-157
2. PubChem CID 16132320 – Thymosin Beta-4
3. PubMed ID 29168963 – “Peptide BPC157 modulates fibroblast migration and cell survival” (Exp Ther Med)
4. PubMed ID 23372382 – “Thymosin β4 and actin cytoskeleton regulation” (J Biol Chem)
5. PubMed ID 30153580 – “Endothelial signaling influenced by β-thymosins” (Front Cell Dev Biol)
6. PubMed ID 34212711 – “BPC-157 and oxidative stress response in cell cultures” (Int J Mol Sci)