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PT-141 Nasal Spray (Bremelanotide, PubChem CID: 6918243) is a synthetic melanocortin receptor agonist derived from the α-MSH analogue Melanotan II. Supplied in buffered aqueous solution, it is employed in laboratory studies of GPCR signaling, peptide stability, and epithelial transport. Provided in high purity for research use only.
PT-141 is cataloged in PubChem as CID 6918243, with the molecular formula C50H68N14O10 and a molecular weight of ~1025.2 g/mol [1]. It is a synthetic cyclic heptapeptide analogue structurally related to Melanotan II, optimized for melanocortin receptor activity.
According to PubChem annotations, PT-141 is a potent agonist of melanocortin receptors (MC3R and MC4R, with activity also at MC1R and MC5R) [1]. In laboratory studies, it is used to probe GPCR-mediated cAMP signaling, receptor selectivity, and downstream transcriptional pathways, making it a key tool in receptor pharmacology research.
The nasal spray preparation provides a delivery format suitable for in vitro epithelial transport, peptide stability, and mucosal diffusion assays [2]. Researchers apply this formulation in comparative studies of peptide absorption kinetics versus injectable solutions, focusing on delivery efficiency and enzymatic degradation.
These applications remain strictly limited to controlled research settings.
PT-141’s PubChem entry includes registry identifiers (CAS 189691-06-3) and standardized structural data [1]. These allow reproducible cataloging, QC verification, and integration into peptide libraries for SAR analysis, bioinformatics tracking, and screening programs.
PT-141 (CID: 6918243) is a cyclic melanocortin receptor agonist widely recorded in PubChem. As a nasal spray formulation, it is employed in controlled studies of melanocortin GPCR signaling, epithelial delivery, and peptide stability. Supplied in high-purity research grade, it is intended for research use only. [1][2]
This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.
