MT-2 Spray

MT-2 Spray

$44.99

MT-2 Nasal Spray (Melanotan II, PubChem CID: 16132316) is a synthetic cyclic heptapeptide analogue of α-MSH. Supplied in buffered aqueous solution, it is designed for research into melanocortin receptor biology, peptide stability, and epithelial transport. Provided at high purity, strictly intended for laboratory research use only.

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Comprehensive PubChem-Based Research Overview

  1. Molecular Identity & Structure

Melanotan II is recorded in PubChem under CID 16132316, with the molecular formula C50H69N15O9 and a molecular weight of ~1024.2 g/mol [1]. Its structure is a cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH), synthesized to enhance receptor affinity and stability.

  1. Receptor Pathways & Mechanistic Studies

PubChem annotations associate MT-2 with melanocortin receptor (MC1R, MC3R, MC4R, MC5R) agonism [1]. In vitro, it is used to probe G-protein coupled receptor (GPCR) signaling, cAMP response assays, and ligand-binding kinetics. The nasal spray format provides a vehicle for studying delivery across epithelial barriers.

  1. Epithelial Transport & Delivery Models

The aqueous nasal spray preparation facilitates laboratory investigations of peptide absorption, stability, and diffusion rates across mucosal models [2]. Researchers use this delivery form to test transport kinetics in cell-based barrier systems or ex vivo epithelial tissue assays, comparing it to lyophilized and injectable preparations.

  1. Cellular & Biochemical Applications

  • Signal Transduction Assays: Examining GPCR activation and downstream cascades.
  • Ligand Screening: Used as a reference agonist in melanocortin receptor libraries.
  • Peptide Stability Testing: Monitoring degradation under physiological pH, enzyme exposure, and epithelial surface conditions.

  1. Traceability & QC Integration

PubChem provides standardized identifiers, including synonyms, structural data, and registry numbers (CAS 121062-08-6) [1]. These ensure reproducibility across laboratories, integration into screening databases, and proper documentation in peptide-focused LIMS or QC pipelines.

Summary

MT-2 (CID: 16132316) is a synthetic cyclic α-MSH analogue widely cataloged in PubChem. The nasal spray formulation enables controlled research into melanocortin receptor signaling, epithelial peptide delivery, and GPCR pharmacology. Supplied in research-grade purity, all applications are limited to laboratory use only. [1][2]

Referenced Citations:

  1. PubChem Compound Summary — Melanotan II (CID: 16132316)
    https://pubchem.ncbi.nlm.nih.gov/compound/16132316
  2. PubChem Substance Record — Melanotan II
    https://pubchem.ncbi.nlm.nih.gov/substance/329754388

Product Usage:

This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.