Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) belongs to the growth hormone secretagogue (GHS) class and exhibits high specificity for GHSR1a with reduced off-target endocrine effects compared with earlier GHRPs.[1] It is widely utilized to probe GH release mechanisms, receptor signaling, and detection methods relevant to sports pharmacology.
Binding studies demonstrate potent activation of GHSR1a, enabling characterization of downstream signaling (e.g., Ca²⁺ mobilization, PKC, and ERK pathways).[1] This selectivity makes ipamorelin a useful reference in receptor profiling assays.
In vitro pituitary and in vivo animal models use ipamorelin to explore pulsatile GH secretion, feedback regulation, and interactions with endogenous ghrelin and GHRH.[1,2] All work is conducted under controlled laboratory protocols.
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