$59.99
IGF-1 LR3 is an 83-amino-acid recombinant analog of insulin-like growth factor-1 with an N-terminal extension and Arg3 substitution. It is used to study IGF-1 receptor signaling, proliferation, differentiation, and survival pathways in cell culture and animal models.
IGF-1 LR3 was engineered to decrease binding to IGF-binding proteins while retaining high affinity for the IGF-1 receptor, thereby increasing bioactivity in vitro.[1] It is a widely used tool in models of muscle biology, cartilage formation, neuronal survival, and metabolic regulation to map downstream PI3K/Akt and MAPK cascades.[2,3] All applications are confined to controlled experimental contexts.
The extended N-terminus and Arg3 substitution reduce sequestration by IGFBPs, effectively increasing free ligand available for receptor activation.[1] This makes IGF-1 LR3 suitable for serum-reduced media, mechanistic phospho-signaling assays, and ligand–receptor binding studies.
In myotube, osteoblast, chondrocyte, and neuronal cultures, LR3 is employed to quantify receptor phosphorylation, protein synthesis, glucose uptake, and survival endpoints.[2,3] These data underpin fundamental understanding of IGF-1 pathway regulation.
In vivo and ex vivo models use LR3 to investigate tissue growth, neuroprotective signaling, and metabolic adaptations, while anti-doping laboratories utilize it as a reference standard for analytical method development. None of these uses imply approved therapeutic protocols.
This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.
