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Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide modeled on pineal extracts. It is used in vitro and in vivo to investigate telomerase regulation, telomere dynamics, circadian biology, and molecular pathways associated with cellular aging and stress responses.
Epithalon is a low-molecular-weight peptide representing the active fragment of epithalamin, introduced as a tool to study genomic stability and aging-related signaling.[1] PubMed-indexed studies report that Epithalon can influence telomerase activity, telomere length, and expression of genes involved in stress resistance and apoptosis in selected models.[2–4] Research focuses on delineating peptide-responsive pathways, not on establishing human therapeutic regimens.
With its short, acidic sequence, Epithalon is suitable for reproducible synthesis and mechanistic assays.[1] In cultured somatic cells and oocyte systems, exposure to Epithalon has been associated with activation of telomerase reverse transcriptase (hTERT) and telomere elongation under specific conditions, suggesting utility as a probe for telomere maintenance mechanisms.[2–4]
Epithalon has been examined for its ability to modulate oxidative stress markers, mitochondrial function, and apoptosis-related proteins. These experiments help clarify connections between telomere regulation, redox balance, and cell survival in aging models.
Because of its origin from pineal peptide complexes, Epithalon is also used to explore circadian gene expression and endocrine rhythm markers.[5] Such work aims to map peptide influences on clock-associated pathways.
This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.
