5 Amino 1MQ Capsules
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5 Amino 1MQ Capsules

$124.99

5-Amino-1MQ (PubChem CID: 1373493) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). It is widely used in research exploring methylation dynamics, NAD+ metabolism, and energy regulation pathways. Provided as a high-purity research compound, it is intended exclusively for controlled laboratory studies, not for human or veterinary use.

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Comprehensive PubChem-Based Research Overview

  1. Molecular Identity & Classification

5-Amino-1MQ, formally known as 5-amino-1-methylquinolinium, is cataloged in PubChem under CID 1373493 with the molecular formula C10H11N2+ [1]. It belongs to the quinolinium class of heteroaromatic compounds and is structurally characterized by a quaternary nitrogen substituent at the 1-position of quinoline. This molecular identity provides the basis for its role as a selective NNMT inhibitor in chemical biology research.

  1. Mechanism of Action: NNMT Inhibition

NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, thereby modulating NAD+ metabolism and cellular methyl donor balance. By blocking NNMT, 5-Amino-1MQ alters downstream nicotinamide and NAD+ fluxes, enabling researchers to dissect pathways of methylation control, redox balance, and metabolic regulation [1].

  1. Research Applications in Cellular Metabolism

  • NAD+ and Energy Studies: NNMT activity has been implicated in regulating intracellular NAD+ pools. Using 5-Amino-1MQ in cultured cells allows quantification of NAD+-linked enzymes and mitochondrial function under inhibited NNMT states [1].
  • Methyl Donor Availability: Inhibition of NNMT shifts the use of SAM, permitting exploration of epigenetic methylation patterns and histone/DNA methylation status in cell-based assays [1].
  • Metabolic Modeling: Experimental use of 5-Amino-1MQ in metabolic flux assays supports studies of obesity, insulin resistance, and altered energy expenditure, though such contexts remain strictly preclinical and mechanistic [1].

  1. Chemical Biology & Assay Development

5-Amino-1MQ’s PubChem entry provides registry identifiers, structure files, and depositor data, ensuring traceability for:

  • Screening libraries focused on NNMT pathway modulators.
  • Structure–activity relationship (SAR) studies comparing quinolinium analogs.
  • Analytical QC via NMR, MS, and chromatographic purity confirmation.

  1. Physicochemical Characteristics

According to PubChem, 5-Amino-1MQ has a monoisotopic mass of ~159.09 g/mol, is classified as a quaternary ammonium compound, and exhibits physicochemical features consistent with cationic solubility profiles. These characteristics guide solubility and formulation considerations in in vitro experiments [1].

Summary

5-Amino-1MQ is a structurally defined quinolinium derivative that selectively inhibits NNMT. It is primarily used in experimental setups probing cellular NAD+ turnover, SAM utilization, and methylation-linked metabolism. Its presence in PubChem ensures reproducibility, traceability, and consistent referencing in bench-scale biochemical, molecular biology, and epigenetics research [1].

Referenced Citations:

  1. PubChem Compound Summary — 5-Amino-1MQ (CID: 1373493)
    https://pubchem.ncbi.nlm.nih.gov/compound/1373493

Product Usage:

This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.