TB500 Spray

TB500 Spray contains a research-grade synthetic peptide fragment corresponding to a region of thymosin beta-4, formulated in a liquid spray format for controlled laboratory applications. This compound is widely used in preclinical investigations focusing on cellular dynamics, cytoskeletal regulation, and tissue-level responses. For research use only. Not for human use.

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TB500 Research Overview

All information below is derived from publicly available scientific data, including PubChem.

TB500 refers to a synthetic peptide consisting of part of the sequence of thymosin beta-4, an actin-binding protein classified as a naturally occurring 43-amino-acid peptide. According to PubChem, thymosin beta-4 is associated with actin-sequestering activity and cytoskeletal organization within eukaryotic cells [1]. TB500, as a truncated analog, is widely used in controlled research environments for studying mechanisms related to cellular structure and motility.

Below are the primary scientific fields where TB500 continues to be investigated.

Cellular Biology & Cytoskeletal Regulation

Thymosin beta-4 is recognized for its high affinity for monomeric G-actin, influencing actin polymerization dynamics [1]. Because TB500 is derived from this parent peptide, researchers frequently use it to investigate:

  • Control of actin assembly
  • Cell migration processes
  • Intracellular transport and signaling
  • Cytoplasmic structural rearrangements

In vitro investigations continue to examine how fragments of thymosin beta-4 influence cytoskeletal architecture and whether specific peptide segments differentially modulate actin-binding properties [1].

Wound-Healing and Tissue Response Models

In preclinical models, thymosin beta-4 has been studied for its role in cell proliferation, cell migration, and extracellular matrix remodeling [1]. TB500 is therefore applied in laboratory studies assessing:

  • Tissue culture response patterns
  • Fibroblast and keratinocyte activity
  • Matrix deposition profiles
  • Angiogenic signaling pathways

These studies do not evaluate clinical outcomes; instead, they focus on understanding biochemical pathways and cellular behaviors relevant to tissue repair models.

Inflammation & Immune Modulation Research

Thymosin beta-4 has been referenced in immunological research exploring cytokine modulation and inflammatory cascades [1]. TB500 continues to be explored for:

  • Immune-cell migration behavior
  • Regulation of inflammatory mediators
  • Interactions between cytoskeletal proteins and immune signaling

These investigations aim to clarify peptide-mediated pathways rather than evaluate therapeutic potential.

Molecular Pathway Mapping

TB500 is also used in structural biology investigations to explore specific peptide regions responsible for actin regulation. PubChem identifies thymosin beta-4’s sequence, structural characteristics, and function, supporting ongoing research into:

  • Actin-binding motifs
  • Protein-protein interaction mapping
  • Identification of peptide regions critical to intracellular regulation [1]

These studies support fundamental understanding rather than applied therapeutic research.

Referenced Citations

  1. Thymosin beta-4 – PubChem
    https://pubchem.ncbi.nlm.nih.gov/compound/16132329

Product Usage:

This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.