$129.99
TAN is a topical research lotion combining Melanotan II and GHK-Cu in a standardized vehicle for advanced pigment biology and extracellular matrix studies. Designed for in vitro and ex vivo skin models, it supports investigation of melanocortin receptor signaling, melanin synthesis pathways, copper homeostasis, and matrix remodeling under controlled conditions.
This formulation integrates two well-characterized research actives: Melanotan II, a synthetic melanocortin receptor agonist, and GHK-Cu, a copper(II)-tripeptide complex. Melanotan II is widely used to probe MC1R/MC4R signaling, cAMP-driven melanogenesis, and downstream transcriptional networks regulating pigment production and UV-response biology.[1,2] GHK-Cu is employed to study copper transport, redox modulation, matrix protein synthesis, and gene expression profiles associated with dermal structure and repair.[3,4] In a topical research matrix, TAN enables simultaneous interrogation of how melanocortin activation and copper-peptide signaling intersect in skin-relevant models, without implying cosmetic or clinical utility.
Co-formulation allows researchers to evaluate spatial and temporal signaling crosstalk in reconstructed epidermis, melanocyte–keratinocyte co-cultures, and dermal equivalents. Endpoints may include melanin content, tyrosinase activity, MC1R pathway activation, collagen and MMP expression, antioxidant gene signatures, and copper-dependent enzymatic activities, using defined exposure parameters.[1–4]
Melanotan II serves as a reference tool for studying melanocortin-driven pigmentation and photoprotective signaling, enabling analysis of cAMP/CREB/MITF pathways and melanosome dynamics.[1,2] TAN provides a ready-to-use medium for such mechanistic work in topical application models.
GHK-Cu contributes a well-studied copper carrier system that can influence ECM-related transcripts, integrin profiles, and antioxidant responses.[3,4] In combination, TAN supports hypothesis-driven research into coordinated pigment and matrix adaptation, remaining strictly within preclinical assays.
This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.
