$79.99
TB500 refers to research-grade thymosin beta-4–derived peptide material used to study actin binding, cell migration, angiogenesis, and tissue remodeling pathways. It is suited for in vitro and in vivo models investigating cytoskeletal regulation and repair-associated signaling, without any approved therapeutic designation.
Thymosin beta-4 (Tβ4) is a 43-amino-acid actin-sequestering peptide; TB500 materials are based on this sequence space and are used as standardized tools in motility and regeneration models.[1] Through defined exposure in cell culture and animal systems, Tβ4-based peptides help elucidate mechanisms governing actin dynamics, directed migration, and extracellular matrix interactions in wound, cardiac, corneal, and other tissues.[2–4] All findings remain exploratory and model-specific.
PubChem records Tβ4 as a highly acidic peptide with strong affinity for G-actin, enabling F-actin/G-actin equilibrium studies and quantitative characterization of cytoskeletal remodeling.[1] TB500-type preparations reproduce key binding motifs, supporting evaluation of actin polymerization, lamellipodia formation, and focal adhesion signaling in a controlled manner.
In fibroblasts, endothelial cells, and keratinocytes, Tβ4-derived peptides have been associated with enhanced migration and reorganization of cytoskeletal and matrix components.[2,3] Researchers employ these reagents to track integrin expression, matrix metalloproteinase activity, and collagen deposition, clarifying peptide-responsive pathways involved in structural repair.
Preclinical models in myocardium, cornea, and dermis use Tβ4-related peptides to study neovascularization, cardiomyocyte survival signaling, and epithelial barrier recovery.[3,4] These experiments delineate molecular targets and pathways but do not establish clinical protocols.
This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.
