Sermorelin

$69.99

Sermorelin acetate (10mg) is a synthetic analog of growth hormone–releasing hormone (GHRH), consisting of the first 29 amino acids of the natural peptide. With ≥99% purity, this research peptide is used in laboratory studies exploring neuroendocrine regulation, aging models, and pituitary function. Supplied for research purposes only.

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Research Applications of Sermorelin (PubChem-Based)

  1. Neuroendocrine Regulation

Sermorelin, a truncated form of GHRH (1–44), retains the full biological activity of the natural hormone in stimulating growth hormone (GH) release from the anterior pituitary. Research highlights its role in characterizing hypothalamic–pituitary signaling pathways and feedback loops involving GH and insulin-like growth factor-1 (IGF-1) [1].

  1. Aging and Developmental Biology

Laboratory studies have utilized Sermorelin to investigate age-related declines in GH secretion and pituitary responsiveness. It has been applied in models of somatopause, providing a controlled tool to analyze differential GH output in juvenile versus aged pituitary cells and animals [2].

  1. Pituitary and Hypothalamic Function

Sermorelin is widely used in research examining pituitary function under normal and stress conditions. Studies demonstrate its value in assessing GH reserve and pituitary responsiveness in controlled research environments. Its defined sequence and stability make it preferable for standardizing stimulation protocols in endocrine testing models [3].

  1. Pharmacological and Biochemical Studies

As a synthetic GHRH analog, Sermorelin provides a reproducible model for peptide-receptor interactions. Investigations using Sermorelin have clarified receptor binding kinetics, peptide degradation rates, and downstream signaling cascades, contributing to understanding peptide pharmacodynamics and pharmacokinetics [4].

  1. Comparative Peptide Research

Sermorelin serves as a benchmark in comparative studies with other GHRH analogs and secretagogues. Researchers employ it to study structural requirements for receptor activation, peptide stability, and signal amplification, aiding peptide design for future experimental use [5].

Referenced Citations:

  1. PubChem Compound Summary for CID 16132238, Sermorelin. PubChem
  2. Sonntag WE, et al. “Alterations in growth hormone secretion and action during aging.” Endocrine Reviews. PubMed
  3. Thorner MO, et al. “Sermorelin: clinical studies on growth hormone release.” Journal of Clinical Endocrinology & Metabolism. PubMed
  4. Frohman LA, et al. “Growth hormone–releasing hormone and its analogs: pharmacology and physiology.” Endocrinology & Metabolism Clinics. PubMed
  5. Veldhuis JD, et al. “Pulsatile and rhythmic growth hormone secretion in man: pathophysiological and pharmacological regulation.” Endocrine Reviews. PubMed

Product Usage:

This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.