$79.99
Dihexa (PubChem CID: 57458948) is a synthetic oligopeptide derivative of angiotensin IV, designed for laboratory studies of synaptic plasticity, neurogenesis, and molecular interactions in the central nervous system. Supplied in high-purity lyophilized form, it is strictly intended for controlled research applications, not for human or veterinary use.
Dihexa, chemically designated as N-hexanoic-L-tyrosyl-L-isoleucine-N-hexylamide, is cataloged in PubChem under CID 57458948 [1]. It is classified as a modified angiotensin IV analogue, where fatty acid extensions enhance lipophilicity and blood–brain barrier permeability. Its molecular formula is C28H45N3O4, with a molecular weight of ~487.7 g/mol [1][2].
Derived from angiotensin IV, Dihexa is structurally altered to extend biological half-life and enhance receptor binding. This classification places it within the synthetic neuropeptide mimetic family, useful for research on cognitive and synaptic processes [1].
PubChem-linked literature indicates Dihexa as a potent facilitator of synaptogenesis [1]. In vitro assays report increased dendritic spine density and synapse formation when neurons are exposed to the compound. These properties make it valuable for studying mechanisms of neural connectivity and structural remodeling.
Experimental data aggregated in PubChem describe Dihexa as acting through modulation of the hepatocyte growth factor (HGF)/c-Met pathway, which plays a role in neuronal survival and synaptic reorganization [2]. Researchers employ it in biochemical assays measuring receptor activation, kinase cascades, and downstream transcriptional changes.
Dihexa’s PubChem record references preclinical data showing effects on memory formation and learning paradigms in animal models [1][2]. While these are strictly non-clinical, they highlight its relevance in mechanistic cognitive research, offering a probe for neuronal circuit plasticity studies.
Its PubChem identifiers allow reproducible integration into screening libraries, SAR studies, and analytical QC pipelines.
Dihexa (CID 57458948) is a synthetic angiotensin IV analogue with enhanced stability and CNS penetration. It is extensively studied in controlled models of synaptogenesis, neurogenesis, and receptor-mediated signaling. Its high-purity synthetic profile and PubChem-documented properties make it a consistent and traceable tool for research use only [1][2].
This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.
