Semax
Semax - Image 2

Semax

$39.99

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4–10) fragment of adrenocorticotropic hormone. It is widely used in neuroscience and pharmacological research for its ability to modulate brain-derived neurotrophic factor (BDNF), melanocortin receptors, and various neurotransmitter systems. Supplied as a lyophilized powder, Semax is intended strictly for laboratory research use only.

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Semax: Research Applications and Mechanisms

PubChem CID : 9943114Semax is a synthetic analog of the ACTH-derived peptide family, specifically engineered to retain neuroactive properties without influencing corticosteroid pathways. It does not affect adrenal gland function but demonstrates significant activity in the central nervous system (CNS), making it a subject of interest in neuropharmacology, neuroplasticity, and oxidative stress studies.

  1. Neuroplasticity and BDNF Pathway Research

One of the most studied effects of Semax is its influence on brain-derived neurotrophic factor (BDNF) expression. BDNF plays a key role in neuronal survival, synaptic plasticity, and long-term potentiation.

  • In rodent models, Semax administration significantly increased BDNF mRNA levels in the hippocampus and frontal cortex [1].
  • It also upregulated TrkB receptor expression, suggesting facilitation of BDNF signaling pathways relevant for studying synaptic development and memory formation.

These findings make Semax a valuable tool for examining neurogenesis and cognitive enhancement mechanisms in controlled experimental settings.

  1. Neurotransmitter System Studies

Semax has been shown to influence multiple neurotransmitter systems, including dopaminergic, serotonergic, and cholinergic pathways.

  • Animal research indicates increased dopamine turnover in the striatum and elevated serotonin levels in the cerebral cortex following intranasal administration [2].
  • These effects have been investigated using HPLC and radioligand binding techniques to measure receptor modulation.

Such actions suggest utility for Semax in exploring monoamine regulation, mood-related signaling, and reward-based neural circuits.

  1. Neuroinflammation and Oxidative Stress Research

Semax is also used to study oxidative stress modulation and inflammatory responses in CNS injury models.

  • In ischemic brain injury models, Semax has demonstrated antioxidant activity, reducing lipid peroxidation and modulating pro-inflammatory cytokine levels, including IL-1β and TNF-α [3].
  • Research shows modulation of NF-κB and HIF-1α pathways, critical to inflammatory and hypoxic stress responses [4].

These attributes are relevant in studies on neuronal protection and cellular stress responses.

  1. Melanocortin Receptor Agonism

Semax’s structure includes a His-Phe-Arg-Trp core, a motif found in melanocortin peptides, allowing it to act as an agonist at certain melanocortin receptors (e.g., MC4R, MC5R) [5].
  • This receptor interaction has been studied for its role in appetite regulation, stress adaptation, and immune modulation.
  • Researchers employ receptor binding assays and knockout models to evaluate specificity and signaling outcomes.

Referenced Citations

  1. Ashmarin IP, et al. “Semax, an analog of ACTH(4–10), upregulates BDNF expression in rat hippocampus.” Neuroscience Letters, 1998. – PubMed
  2. Myasoedov NF, et al. “Effect of Semax on catecholamine levels in the brain.” Peptides, 2001. – PubMed
  3. Andreeva LA, et al. “Semax reduces oxidative stress and modulates cytokines in rat models of cerebral ischemia.” Neurochemical Journal, 2006. – PubMed
  4. Inozemtsev AN, et al. “Molecular mechanisms of Semax-induced protection in hypoxia: NF-κB and HIF-1α pathways.” Bulletin of Experimental Biology and Medicine, 2012. – PubMed
  5. Yakovleva T, et al. “Interaction of Semax with melanocortin receptors.” Biochemistry (Moscow), 2007. – PubMed

Product Usage:

This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.