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Kisspeptin-10 is a synthetic decapeptide corresponding to the C-terminal fragment of the KISS1 gene product, with the sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 and a molecular formula of C63H83N17O14 (PubChem CID 25240297) [1]. It is the shortest kisspeptin fragment that retains full intrinsic activity at the kisspeptin receptor KISS1R, also called GPR54 [2]. Laboratories use it as a reference ligand in work on the hypothalamic-pituitary-gonadal axis, gonadotropin release, pubertal signaling, metabolic regulation, and KISS1-related tumor biology. Supplied as a lyophilized powder in a 10 mg vial for in vitro and preclinical laboratory applications. This material is sold for research purposes only and is not intended for human or veterinary consumption.
Kisspeptin-10 is widely used as a probe for GnRH-driven gonadotropin release. Kisspeptins were identified as the endogenous agonists of GPR54, binding at low nanomolar affinity and triggering PIP2 hydrolysis, calcium mobilization, and MAP kinase phosphorylation [3]. Controlled comparative work in healthy male subjects evaluated kisspeptin-10, kisspeptin-54, and GnRH across three infusion rates, characterizing kisspeptin-10 as a less potent but more physiologically patterned stimulus than direct pituitary stimulation with GnRH [4]. Comparable LH and FSH responses have been documented in prepubertal cattle models following intravenous and intramuscular administration [5].
Because kisspeptin acts upstream of GnRH, the peptide is used to interrogate where estrogen and progesterone feedback occurs. Research across different sex steroid backgrounds in women indicates that the gonadotropin response to kisspeptin-10 varies with the prevailing steroid milieu, supporting the pituitary gonadotrope as a functionally relevant site of feedback [6]. Rodent studies have separately established a central stimulatory effect of KISS1 peptides on FSH release specifically, distinguishing it from the better-characterized LH response [7].
KISS1 was originally characterized as a metastasis suppressor gene, and its peptide products are studied for effects on cell motility, adhesion, invasion, and matrix metalloproteinase activity [8]. Investigations in endometrial cancer models have examined metastin-10 as a suppressor of invasion in GPR54-expressing tumors [9]. Other work reports context-dependent results, including kisspeptin-10 stimulating invasiveness in specific breast cancer cell lines through EGFR transactivation, which makes the peptide useful for probing tissue-specific KISS1R signaling [10].
GPR54 expression has been detected in pancreatic islets, and kisspeptin-10 is used alongside GLP-1 to compare Gq-coupled versus Gs-coupled potentiation of insulin secretion, intracellular calcium activity, and cellular redox state in intact murine islets [11]. Longer-term rodent work has examined kisspeptin-10 administration in high-fat-fed models, reporting changes in glucose homeostasis, energy intake, enteroendocrine cell populations, and islet morphology [12].
Functional MRI studies have used kisspeptin administration to map limbic activity in response to sexual and emotional stimuli in healthy adult volunteers [13], with follow-up work examining effects on resting-state brain connectivity and network organization [14]. These paradigms position the peptide as a tool for studying the interface between reproductive endocrinology and affective neuroscience.
This product is intended for laboratory research use only. It is not a drug, food, dietary supplement, or cosmetic, and it is not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease. It is not for human or animal consumption. Handling should be restricted to qualified personnel in an appropriate laboratory setting.
This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.
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