BPC-157/TB500 Spray

BPC-157/TB500 Spray

$79.99

BPC-157 / TB-500 blend pairs two synthetic peptides that appear together frequently in tissue repair and cell migration literature. BPC-157 is a 15 amino acid sequence corresponding to a partial region of a protein found in human gastric juice. TB-500 is the N-acetylated 17 to 23 fragment of thymosin beta-4, the segment responsible for actin binding. Each unit contains 5 mg of each peptide. Supplied strictly as a laboratory reference material for in vitro and preclinical investigation. Not a drug, supplement, or food. Not for human or veterinary use.

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Applications in Research

  1. Angiogenesis and Vascular Signaling

BPC-157 has been examined for its association with VEGFR2 expression and VEGFR2-Akt-eNOS pathway activation in endothelial tube formation assays and a rat hind limb ischemia model [1].

  1. Fibroblast Migration

In cultured rat tendon fibroblasts, BPC-157 was associated with dose-dependent migration increases and elevated FAK and paxillin phosphorylation, with no direct effect on proliferation [2].

  1. Actin Cytoskeletal Dynamics

TB-500 corresponds to the actin-binding domain of thymosin beta-4, the principal G-actin sequestering molecule in eukaryotic cells, making it a common reference compound in actin polymerization and cell motility assays [3].

  1. Tissue Repair Models

Thymosin beta-4 has been studied in dermal wound models [4] and in cardiac injury models, where it formed a complex with PINCH and integrin-linked kinase and activated Akt following coronary artery ligation in mice [5].

Referenced Citations:

BPC-157 mechanistic work comes primarily from the Chang Gung University group in Taiwan and the Sikiric group in Croatia. TB-500 characterization originates with Goldstein and Kleinman at George Washington University and the NIH. All references are indexed in PubMed or PubChem.

  1. Hsieh MJ, et al. J Mol Med (Berl). 2017;95(3):323-333. PMID: 27847966.
    https://pubmed.ncbi.nlm.nih.gov/27847966/
  2. Chang CH, et al. J Appl Physiol. 2011;110(3):774-780. PMID: 21030672.
    https://pubmed.ncbi.nlm.nih.gov/21030672/
  3. Goldstein AL, et al. Trends Mol Med. 2005;11(9):421-429. PMID: 16099219.
    https://pubmed.ncbi.nlm.nih.gov/16099219/
  4. Malinda KM, et al. J Invest Dermatol. 1999;113(3):364-368. PMID: 10469335.
    https://pubmed.ncbi.nlm.nih.gov/10469335/
  5. Bock-Marquette I, et al. Nature. 2004;432(7016):466-472. PMID: 15565145.
    https://pubmed.ncbi.nlm.nih.gov/15565145/
  6. PubChem CID 9941957, BPC-157.
    https://pubchem.ncbi.nlm.nih.gov/compound/9941957
  7. PubChem CID 62707662, TB-500.
    https://pubchem.ncbi.nlm.nih.gov/compound/62707662

Product Usage:

This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.

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