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100% manufactured in the USABatch-specific COAs on tested lots76 research compounds in stockFor research use onlyFree shipping on orders over $200100% manufactured in the USABatch-specific COAs on tested lots76 research compounds in stockFor research use onlyFree shipping on orders over $200100% manufactured in the USABatch-specific COAs on tested lots76 research compounds in stockFor research use onlyFree shipping on orders over $200100% manufactured in the USABatch-specific COAs on tested lots76 research compounds in stockFor research use onlyFree shipping on orders over $200
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5-Amino 1MQ research vial
COA ON FILEMADE IN USA
Single Peptides

5-Amino 1MQ

$55.99$11.20/mg
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Manufactured in the USA
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Description

5-Amino 1MQ (5-amino-1-methylquinolinium) is a small-molecule NNMT inhibitor, not a peptide. Supplied as a lyophilized powder in sealed vials. Each batch has its own certificate of analysis (COA), which opens when you scan the QR code on the label. For laboratory research use only. Not for human or veterinary use.

Research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease.
Research profile

5-Amino-1MQ research profile

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule quaternary quinolinium cation that inhibits nicotinamide N-methyltransferase (NNMT) by binding at the nicotinamide substrate site. It came out of a structure-activity study of N-methylated aromatic scaffolds by Neelakantan, Watowich and colleagues at the University of Texas Medical Branch in 2017. It is usually supplied as the iodide salt.

Specifications

Chemical name
5-Amino-1-methylquinolin-1-ium (iodide salt)
Molecular formula
C10H11N2+ (cation); C10H11N2·I (iodide salt)
Molecular weight
≈ 159.2 g/mol (cation); 286.1 g/mol (iodide salt)
CAS number
42464-96-0 (iodide salt)
Target
Nicotinamide N-methyltransferase (NNMT), IC50 ≈ 1.2 µM
Size
5MG / 50MG per vial
Form
Lyophilized powder, sealed vial
Storage
Keep sealed, protected from light and moisture; follow the label
Testing
HPLC purity and mass spectrometry identity, per lot. Scan the QR code on the vial for the certificate of analysis.

Published research

  • Structure-activity relationships of quinolinium and related NNMT inhibitors, with docking to the substrate site (Neelakantan et al., J Med Chem, 2017).
  • Permeability (PAMPA, Caco-2), selectivity against related methyltransferases, and 1-methylnicotinamide, NAD+ and SAM levels in cultured adipocytes (Neelakantan et al., Biochem Pharmacol, 2018).
  • The same 2018 study measured body weight, white adipose mass and plasma cholesterol in diet-induced obese mice.
  • Target background: NNMT knockdown in adipose tissue and liver of mice (Kraus et al., Nature, 2014).

Frequently asked questions

What does NNMT do?

It transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide.

Why do two molecular weights appear?

The active species is the cation (≈ 159.2 g/mol); it is supplied as a salt, usually the iodide (286.1 g/mol). The COA states the form tested.

How do I verify my lot?

Scan the QR code on the vial. It opens the certificate of analysis for that lot, with HPLC purity and the mass spectrometry identity result.

For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Literature references are provided for scientific context and do not describe this product's suitability for any use.

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