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Single Peptides
ARA 290
$69.99
Description
ARA 290 is a synthetic 11-amino-acid peptide derived from the helix B region of erythropoietin. Supplied as a lyophilized powder in sealed vials. Each batch has its own certificate of analysis (COA), which opens when you scan the QR code on the label. For laboratory research use only. Not for human or veterinary use.
Research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease.
Research profile
ARA-290 research profile
ARA-290 (cibinetide) is an 11-residue peptide designed from the aqueous face of helix B of erythropoietin. It was built to engage the EPOR/CD131 "innate repair receptor" without stimulating red-cell production, and was described by Brines, Cerami and colleagues in 2008.
Specifications
- Sequence
- pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (pE-EQLERALNSS)
- Molecular formula
- C51H84N16O21
- Molecular weight
- ≈ 1257.3 g/mol
- CAS number
- 1208243-50-8
- Form
- Lyophilized powder, sealed vial
- Storage
- Keep sealed, protected from light and moisture; follow the label
- Testing
- HPLC purity and mass spectrometry identity, per lot. Scan the QR code on the vial for the certificate of analysis.
Published research
- Tissue-protection models: rat spinal cord cultures, rodent stroke, rat diabetic retinal edema, sciatic nerve compression and mouse renal ischemia-reperfusion, without erythropoietic activity (Brines et al., PNAS, 2008).
- Small-fiber neuropathy: Phase 2 placebo-controlled study (Brines et al., Mol Med, 2014).
- Corneal nerve fibres: Phase 2b study in sarcoidosis-associated small nerve fibre loss (Culver et al., Invest Ophthalmol Vis Sci, 2017).
Frequently asked questions
What is cibinetide?
The international nonproprietary name for ARA-290.
What does pGlu mean?
Pyroglutamate, a cyclized N-terminal glutamine or glutamate residue.
How do I verify my lot?
Scan the QR code on the vial. It opens the certificate of analysis for that lot, with HPLC purity and the mass spectrometry identity result.
For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Literature references are provided for scientific context and do not describe this product's suitability for any use.
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