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Single Peptides
TB500
$79.99
Description
TB500 is a synthetic peptide derived from the thymosin beta-4 sequence. Supplied as a lyophilized powder in sealed vials. Each batch has its own certificate of analysis (COA), which opens when you scan the QR code on the label. For laboratory research use only. Not for human or veterinary use.
Research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease.
Research profile
TB-500 research profile
TB-500 is the name most commonly used for the synthetic N-acetylated fragment Ac-LKKTETQ, residues 17–23 of thymosin beta-4 (Tβ4). This short stretch contains the LKKTET actin-binding motif. Some sources use "TB-500" for full-length Tβ4, so the identity of each lot should be confirmed by mass spectrometry on its certificate of analysis.
Specifications
- Sequence
- Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-OH (Ac-LKKTETQ), Tβ4 residues 17–23
- Molecular formula
- C38H68N10O14
- Molecular weight
- ≈ 889.0 g/mol
- CAS number
- 885340-08-9
- Parent protein
- Thymosin beta-4, 43 residues, ≈ 4963.5 g/mol, CAS 77591-33-4
- Form
- Lyophilized powder, sealed vial
- Storage
- Keep sealed, protected from light and moisture; follow the label
- Testing
- HPLC purity and mass spectrometry identity, per lot. Scan the QR code on the vial for the certificate of analysis.
Published research
- Actin biology: Tβ4 identified as the main actin-sequestering protein in cells (Safer et al., J Biol Chem, 1991).
- Wound models: topical TB-500 in mouse skin wounds (Huang et al., Proteomics, 2006); Tβ4 in rat skin wounds (Malinda et al., J Invest Dermatol, 1999).
- Cardiac models: Tβ4 in mouse coronary ligation and cultured cardiomyocytes (Bock-Marquette et al., Nature, 2004).
- Analytical chemistry: characterization and detection of the fragment and its metabolites (Esposito et al., Drug Test Anal, 2012).
Frequently asked questions
Is TB-500 the same as thymosin beta-4?
Not exactly. TB-500 most commonly refers to the 7-residue fragment Ac-LKKTETQ (≈ 889 g/mol) from thymosin beta-4, a 43-residue protein (≈ 4963 g/mol). The mass spectrometry result on the COA shows which is in the vial.
What is the LKKTET motif?
It is the actin-binding region of thymosin beta-4, contained within the TB-500 fragment.
How do I verify my lot?
Scan the QR code on the vial. It opens the certificate of analysis for that lot, with HPLC purity and the mass spectrometry identity result.
For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Literature references are provided for scientific context and do not describe this product's suitability for any use.
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