Adamax and Semax: what is known about this analog
Adamax is a synthetic analog in the Semax peptide family. Unlike its parent peptide, it has very little peer-reviewed literature. This guide separates what is documented from what is not.
The parent peptide: Semax
- Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
- Design: the ACTH(4–7) fragment (Met-Glu-His-Phe) extended with Pro-Gly-Pro for greater resistance to peptidases
- Origin: Institute of Molecular Genetics, Russian Academy of Sciences
- Literature: an extensive body of rodent and in vitro research
What makes Adamax different
Public chemical databases describe Adamax as a Semax-type heptapeptide core with terminal modifications, including an adamantane-based group at the C-terminus. The reported molecular formula is C50H69N11O11S, about 1032.2 g/mol. Sources do not fully agree on every structural detail, so these values should be treated as reported rather than settled.
Why adamantane?
Adamantane is a rigid, cage-shaped hydrocarbon. Medicinal chemists attach it to molecules to increase lipophilicity and resistance to metabolic breakdown. It appears in several well-studied small molecules, and adding it to peptides is an established research strategy.
What is not known
There is little peer-reviewed data specific to Adamax: no large body of published pharmacology, stability or analytical studies. Claims about it should be read with that in mind.
Why the certificate of analysis matters here
For a compound with limited literature, the identity result is the most important panel on the certificate. The mass spectrometry result should match the expected mass for the stated structure. See how mass spectrometry confirms identity, then scan the QR code on your vial to open that lot’s report.
Related
Selank is another Pro-Gly-Pro-extended peptide from the same institute. See Selank explained.
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- How to read a certificate of analysis (COA)
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For laboratory research use only. Not for human or veterinary use. This guide summarizes published scientific literature for context. It is not medical advice and does not describe any product as suitable for human use.