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COA ON FILEMADE IN USA
Capsules
5 Amino 1MQ Capsules
$124.99
Description
5-Amino 1MQ, a small-molecule NNMT inhibitor, in capsule format for formulation research. Each batch has its own certificate of analysis (COA), which opens when you scan the QR code on the label. For laboratory research use only. Not for human or veterinary use.
Research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease.
Research profile
5-Amino-1MQ research profile
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule quaternary quinolinium cation that inhibits nicotinamide N-methyltransferase (NNMT) by binding at the nicotinamide substrate site. It came out of a structure-activity study of N-methylated aromatic scaffolds by Neelakantan, Watowich and colleagues at the University of Texas Medical Branch in 2017. It is usually supplied as the iodide salt.
Specifications
- Chemical name
- 5-Amino-1-methylquinolin-1-ium (iodide salt)
- Molecular formula
- C10H11N2+ (cation); C10H11N2·I (iodide salt)
- Molecular weight
- ≈ 159.2 g/mol (cation); 286.1 g/mol (iodide salt)
- CAS number
- 42464-96-0 (iodide salt)
- Target
- Nicotinamide N-methyltransferase (NNMT), IC50 ≈ 1.2 µM
- Form
- Supplied in capsule format
- Storage
- Keep sealed, protected from light and moisture; follow the label
- Testing
- HPLC purity and mass spectrometry identity, per lot. Scan the QR code on the vial for the certificate of analysis.
Published research
- Structure-activity relationships of quinolinium and related NNMT inhibitors, with docking to the substrate site (Neelakantan et al., J Med Chem, 2017).
- Permeability (PAMPA, Caco-2), selectivity against related methyltransferases, and 1-methylnicotinamide, NAD+ and SAM levels in cultured adipocytes (Neelakantan et al., Biochem Pharmacol, 2018).
- The same 2018 study measured body weight, white adipose mass and plasma cholesterol in diet-induced obese mice.
- Target background: NNMT knockdown in adipose tissue and liver of mice (Kraus et al., Nature, 2014).
Frequently asked questions
What does NNMT do?
It transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide.
Why do two molecular weights appear?
The active species is the cation (≈ 159.2 g/mol); it is supplied as a salt, usually the iodide (286.1 g/mol). The COA states the form tested.
How do I verify my lot?
Scan the QR code on the vial. It opens the certificate of analysis for that lot, with HPLC purity and the mass spectrometry identity result.
For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Literature references are provided for scientific context and do not describe this product's suitability for any use.
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