COAUSA
Cardiogen
Bioregulators
$59.99$3.00/mg
COA ON FILEMADE IN USA
Bioregulators
Pancragen
$59.99$3.00/mg
Description
Pancragen is a synthetic short-chain tetrapeptide bioregulator (Lys-Glu-Asp-Trp). Supplied as a lyophilized powder in sealed vials. Each batch has its own certificate of analysis (COA), which opens when you scan the QR code on the label. For laboratory research use only. Not for human or veterinary use.
Research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease.
Research profile
Pancragen research profile
Pancragen is the name used for the synthetic tetrapeptide Lys-Glu-Asp-Trp (KEDW). Several Khavinson-group publications and the developers' patent describe it as the C-terminal amide (KEDW-NH2). Research has focused on pancreatic cell cultures and on how the peptide interacts with DNA and histones.
Specifications
- Sequence
- Lys-Glu-Asp-Trp (KEDW); described in some sources as the C-terminal amide, KEDW-NH2
- Molecular formula
- C26H36N6O9 (free acid)
- Molecular weight
- ≈ 576.6 g/mol (free acid; the amide form is ≈ 575.6 g/mol)
- Size
- 20MG per vial
- Form
- Lyophilized powder, sealed vial
- Storage
- Keep sealed, protected from light and moisture; follow the label
- Testing
- HPLC purity and mass spectrometry identity, per lot. Scan the QR code on the vial for the certificate of analysis.
Published research
- Pancreatic cell differentiation: Pdx1, Ptf1a, Pax6, Pax4, Foxa2 and Nkx2.2 expression in "young" and "aged" pancreatic cell cultures (Khavinson et al., Bull Exp Biol Med, 2013).
- DNA interaction and gene expression: KEDW binding to DNA studied alongside gene-expression measurements (Khavinson et al., Am J Biomed Sci, 2015).
- Chromatin: binding of fluorescently labelled AEDG, EDR, AEDL and KEDW to histones (Fedoreyeva et al., Biochemistry (Moscow), 2013).
- The tetrapeptide amide Lys-Glu-Asp-Trp-NH2 is described in the developers' patent (Khavinson et al., US Patent 7,491,703, 2009).
Frequently asked questions
Is Pancragen an amide or a free acid?
Both forms appear in the literature. The profile lists values for the free acid (≈ 576.6 g/mol) and the amide (≈ 575.6 g/mol); the mass spectrometry result on the COA shows which form is in the vial.
What is the sequence of Pancragen?
Lys-Glu-Asp-Trp (KEDW), a tetrapeptide.
How do I verify my lot?
Scan the QR code on the vial. It opens the certificate of analysis for that lot, with HPLC purity and the mass spectrometry identity result.
For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Literature references are provided for scientific context and do not describe this product's suitability for any use.
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