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100% manufactured in the USABatch-specific COAs on tested lots76 research compounds in stockFor research use onlyFree shipping on orders over $200100% manufactured in the USABatch-specific COAs on tested lots76 research compounds in stockFor research use onlyFree shipping on orders over $200100% manufactured in the USABatch-specific COAs on tested lots76 research compounds in stockFor research use onlyFree shipping on orders over $200100% manufactured in the USABatch-specific COAs on tested lots76 research compounds in stockFor research use onlyFree shipping on orders over $200
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MOTS-C research vial
COA ON FILEMADE IN USA
Single Peptides

MOTS-C

$69.99$7.00/mg
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Manufactured in the USA
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Description

MOTS-C is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene. Supplied as a lyophilized powder in sealed vials. Each batch has its own certificate of analysis (COA), which opens when you scan the QR code on the label. For laboratory research use only. Not for human or veterinary use.

Research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease.
Research profile

MOTS-c research profile

MOTS-c is a 16-residue peptide encoded by a short open reading frame inside the mitochondrial 12S rRNA gene (MT-RNR1). It was discovered by Changhan Lee and colleagues in Pinchas Cohen's laboratory and reported in Cell Metabolism in 2015, making it one of the best-known mitochondrial-derived peptides.

Specifications

Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)
Molecular formula
C101H152N28O22S2
Molecular weight
≈ 2174.6 g/mol
CAS number
1627580-64-6
Sizes
10 mg, 20 mg and 40 mg
Form
Lyophilized powder, sealed vial
Storage
Keep sealed, protected from light and moisture; follow the label
Testing
HPLC purity and mass spectrometry identity, per lot. Scan the QR code on the vial for the certificate of analysis.

Published research

  • Discovery and metabolic signalling: cultured cells and diet-induced obesity mouse models, AMPK and folate-cycle pathways (Lee et al., Cell Metab, 2015).
  • Exercise and aging: aged-mouse studies; MOTS-c levels in plasma and muscle measured around exercise (Reynolds et al., Nat Commun, 2021).
  • Cardiac models: diabetic rat myocardial injury (Tang et al., Sci Rep, 2023).
  • Reviews of the mitochondrial-derived peptide family: Mohtashami et al., Int J Mol Sci, 2022; Wan et al., J Transl Med, 2023.
Read the guide MOTS-c: the mitochondrial-derived peptide explained

Frequently asked questions

What is a mitochondrial-derived peptide?

A peptide encoded within mitochondrial DNA rather than the nuclear genome. MOTS-c is encoded in the 12S rRNA gene.

What sizes are available?

10 mg, 20 mg and 40 mg.

How do I verify my lot?

Scan the QR code on the vial. It opens the certificate of analysis for that lot, with HPLC purity and the mass spectrometry identity result.

For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Literature references are provided for scientific context and do not describe this product's suitability for any use.

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